Clinical and Economic Impact of Oxidized Regenerated Cellulose for Surgeries in a Chinese Tertiary Hospital

Recently, the collaborative real-world study between Xiangya Hospital of Central South University and Normin Health, titled "Clinical and economic impact of oxidized regenerated cellulose for surgeries in a Chinese tertiary care hospital," was successfully published in the Journal of Comparative Effectiveness Research. The study evaluated the clinical and economic impact of oxidized regenerated cellulose (ORC) compared to conventional non-ORC hemostatic techniques across ten major surgical procedures in a leading Chinese tertiary hospital.

Key Highlights of the Study:

Study Design & Matched Cohort: A retrospective cohort study utilizing propensity-score matching across ten surgical categories to compare perioperative blood transfusion volume and total hospital costs between ORC and non-ORC groups.

Major Findings:

Procedure-Specific Hemostatic & Cost Benefits: Non-ORC was associated with significantly higher blood transfusion volumes and higher total hospital costs across six major surgical types, including endoscopic transnasal sphenoidal surgery, non-skull base craniotomy, hepatectomy, cholangiotomy, gastrectomy, and lumbar surgery.

Value of Procedure-Stratified Device Strategy: The clinical and economic value of adjunctive hemostats varied markedly by surgical complexity, demonstrating that hospital management should adopt procedure-tailored usage criteria rather than blanket restrictions.

Clinical and Policy Implications:

This study provides hospital administrators, surgical departments, and medical device manufacturers with a pragmatic, real-world evidence framework. It illustrates how linking surgical indications, perioperative clinical endpoints, and hospital accounting data can inform value-based hospital procurement and clinical pathway optimization.

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